Curated hyperbaric oxygen therapy evidence, organised by indication and graded by study design.
Every entry is an appraisal from Dr Gregory Weir's maintained HBOT clinical wiki — positive and null
trials both included — and, where the source is indexed, links to its PubMed record and DOI.
360appraised sources
17recognised indications
267RCT / SR / meta
312practice appraisals
311UNSW appraisals
1967–2026years covered
Indications
The SAUHMA/UHMS-recognised indications this unit treats. Select one to see its evidence.
Two different things are shown — please don't conflate them:
SAUHMA Grade A / B / C is the strength of the society recommendation
for the indication — how strongly HBOT is recommended, not the design of any single study.
An indication shown without a grade badge is one for which no SAUHMA A/B/C grade is on record —
typically a composite or multi-condition indication the society has not graded as a single entity. A
grade is a society determination, so none is inferred here; absence of a badge is not a judgement about
the strength of the evidence, which is set out on the cards themselves.
The study-design badge on each source (RCT, systematic review, meta-analysis,
cohort, guideline…) reflects the methodological hierarchy of the evidence. It indicates design only —
it is not a formal GRADE appraisal.
The number beside each indication is a count of appraised records, not a
measure of evidence strength. A few strong, on-point studies can matter more than many heterogeneous or
overlapping ones — read the qualitative appraisal on each card.
Appraised evidence (360)
Practice appraisals — hbo.co.za (312)
UNSW CAT appraisals (311)
Critically-appraised topics written in-house by hbo.co.za + Anthropic Claude using the
Python CATmaker & Appraisal Scripts (CEBM CATmaker method; RoB 2 / AMSTAR-2 → OCEBM level → GRADE).
Each carries a GRADE certainty and is cross-linked to its evidence page.
Secondary appraisals imported (with attribution) from the UNSW HBO Evidence database —
The HBOE Working Group under the late Clinical A/Prof. M.H. Bennett. Reference material, not this practice's
own appraisals.